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Fmoc-Thr[GalNAc(Ac)3-α-D]-OH

CAS No. 116783-35-8

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH ( Fmoc-Thr(Ac?AcNH-α-Gal)-OH )

Catalog No. M29865 CAS No. 116783-35-8

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 60 Get Quote
5MG 98 Get Quote
10MG 147 Get Quote
25MG 246 Get Quote
50MG 425 Get Quote
100MG 608 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote

Biological Information

  • Product Name
    Fmoc-Thr[GalNAc(Ac)3-α-D]-OH
  • Note
    Research use only, not for human use.
  • Brief Description
    AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
  • Description
    AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.(In Vitro):The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.
  • Synonyms
    Fmoc-Thr(Ac?AcNH-α-Gal)-OH
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    116783-35-8
  • Formula Weight
    670.7
  • Molecular Formula
    C33H38N2O13
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Ju T, et al. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 1;14(1):63-81.
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